![]() This helpline is a free resource at no cost to the caller. We do not receive any compensation or commission for referrals to other treatment facilities. If one of our treatment centers is not a good fit, our representatives may refer you to another detox or treatment center, or the Substance Abuse and Mental Health Services Administration ( SAMHSA) hotline to find a program that best suits your needs. You nor your loved one are under any obligation to commit to an Ark Behavioral Health treatment program when calling our helpline. When you call our helpline, you’ll be connected with a representative who can assist you in finding mental health and addiction treatment resources at any of the Ark Behavioral Health addiction treatment facilities. This helpline is answered by Ark Behavioral Health, an addiction treatment provider with treatment facilities in Massachusetts and Ohio. The helpline at is available 24/7 to discuss the treatment needs of yourself or a loved one. It can also complicate the process of identifying a correct dose of methadone for stabilization. All in all, it’s generally advised that those who are taking methadone avoid drinking grapefruit juice when possible.ĭrinking grapefruit juice while on methadone could disrupt a person’s methadone treatment. Is Drinking Grapefruit Juice While On Methadone Dangerous? Regularly drinking grapefruit juice, or eating grapefruit, could increase the levels of methadone in a person’s blood and thereby enhance the effects of methadone. Grapefruit are a known inhibitor of an enzyme called cytochrome P450 (CYP) 34A, which plays a major role in the metabolism of methadone in the liver. Learn more about negative drug interactions with methadone How Grapefruit Juice Interacts With Methadone Understanding the potential risks and effects of this interaction may be important if you or a loved one is taking methadone or plans on taking methadone. Methadone is a medication for opioid use disorder that can interact with a variety of drugs and other substances, including grapefruit juice. Eating grapefruit or drinking grapefruit juice may increase the effects of methadone and therefore interfere with a person’s treatment. ![]() Grapefruit inhibits an enzyme that is involved in the body’s process of metabolizing methadone.
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